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The future of cloning

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AUSTRALIA’S laws on stem cells and human cloning are under review. A committee headed by former Federal Court Justice John Lockhart has called for public submissions 9 September. So where’s the fervent public debate?

 Our laws currently ban any form of human cloning. Cloning a human being—so-called reproductive cloning—is clearly unethical, not least because it would produce a very sick individual. But cloning some cells from a person—so-called therapeutic cloning—is a different kettle of fish.

 To understand the potential of therapeutic cloning, let’s indulge in a little future gazing. The year is 2020. The place is Seoul, South Korea—the world capital of “Regenerative Medicine.”

 Three-year-old Emma has juvenile diabetes—caused deterioration of the islet cells which produce insulin in her pancreas. Twenty years ago, she would have been treated with insulin injections. But they didn’t always halt the blindness or kidney failure that came with the disease. Sometimes adults with Emma’s condition were lucky enough to get an islet graft from a donated pancreas, but then they had to take anti-rejection drugs for the rest of their lives—not advisable for kids.

 Now, in 2020, Emma and her mum have made the trip from Melbourne to receive the treatment for which the Seoul clinic is famous. Emma has skin cells scraped from the side of her cheek. Meanwhile her mother, after treatment with hormones, has 10 eggs harvested from her swollen ovary.

 In the lab, a steady-handed technician, wielding two fine needles under a microscope, plucks out the dark round nucleus from one of Emma’s skin cells. He inserts it into one of her mother’s eggs, from which the nucleus has been removed. Emma’s skin nucleus carried her genetic blueprint. Now inside her mother’s egg, it will start multiplying forming an embryo that is a clone of Emma.

 After the embryo has divided about seven times, forming a hollow ball of about 100 cells, the technician will remove a clump of them that nestle in the interior. This clump will give rise to embryonic stem cells—biological gold. Embryonic stem cells multiply endlessly to produce the large numbers of cells needed for a graft, and they have the potential to mature into any tissue of the body. In this case, the stem cells will be matured into islet cells which, when grafted into Emma’s pancreas, will cure her diabetes. And, because the graft is made up of Emma’s own cells, it will not need to be accompanied deadly immune-suppressing drugs.

 In the bone marrow section of the clinic, we find 30-year-old Josh. He has leukaemia. His bone marrow is about to be destroyed to kill off the cancer cells, but this cannot be done until he has a replacement graft of bone marrow cells. Twenty years ago people often died waiting for a matching donor, or died from a graft that wasn’t a good enough match. Josh is at the clinic to generate his own matching graft. The starting source, as for Emma, is his skin cells. This time, it is his girlfriend who is donating the eggs. Josh’s cloned embryo will again provide the embryonic stem cells, but this time the stem cells will go through a different maturation process, to produce primitive bone marrow cells, not islets.

 Five-year-old Peter is at the clinic too. He has Falconi’s anaemia, a blood disease caused the loss of a single gene. Before technicians make up his bone marrow graft, they will replace the missing gene in his embryonic stem cells. Then, they will multiply them, and instruct them to mature as bone marrow cells.

 In the neurology section we meet Mary, a 55-year-old with Parkinson’s disease, and her niece who is donating the eggs. Mary’s embryonic stem cells will be matured into dopamine-producing brain cells. These will be grafted into her brain to replace the cells that died off and caused her disease.

 Back in Australia in 2020, things have changed dramatically for patients with motor neuron diseases, such as ALS or transverse myelitis. These conditions strike out of the blue killing off motor neurons. In the worst cases, patients progressively lose the ability to walk, talk, eat and breathe. Twenty years back, no-one knew how to halt the death of the neurons, because there was no way to study the disease. But in Korea they used therapeutic cloning to make embryonic stem cells from people with these diseases. Those cells were matured into motor neurons, which researchers employed as “model patients” in their studies. Korean drug companies used these cells to screen drugs, and found a compound that halts the death of the motor neurons. Now these diseases are no longer a death sentence.

 This futurology is not fanciful. In 2002 and 2003, researchers carried out these exact therapeutic cloning techniques in mice with Parkinson’s disease and genetic blood diseases. They cured the mice.

 In 2005, using drug screens, researchers found a compound that might help save motor neurons in kids with Spinal Muscular Atrophy—a disease that kills motor neurons in new born babies. Trouble is, they didn’t have the real, affected cells. For a drug screen you need cells that multiply readily; the best thing they could get were mouse brain cancer cells. With therapeutic cloning, they could have tested their drugs on motor neurons derived from the skin cells of sick kids.

Opponents of this future scenario claim that therapeutic cloning is unnecessary because adult stem cells, which we carry in some of our organs, will provide all the same benefits. I wonder how they know that. Because if there is anything we have learned from the progress of science, it is that, like football, we don’t know how to pick winners. As historian Daniel Boorstin put it, “ the greatest obstacle to discovery is not ignorance, it is the illusion of knowledge”.

 Elizabeth Finkel is a Melbourne scientist, writer and author of Stem Cells – controversy at the Frontiers of Science.


Tassie teacher takes action on science literacy

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Throughout Australia’s National Science Week, eminent scientists called for urgent action to get more young people interested in science and engineering.

Nobel Laureate Harry Kroto said, “The human race is not going to survive unless some smart kids solve some truly fundamental sustainability problems.”

“But not enough kids want to go into science and engineering to solve them,” said Kroto.

Kroto’s concerns reflected those of UK roboticist Noel Sharkey.

“The number of engineers in the west is dropping dramatically. It seems dull and boring to people, whereas if you go to India or China everybody there wants to be an engineer,” says Sharkey.

“We need to enthuse the next generation of scientists and engineers.”

Enter Exeter High School science teacher Jane Dadson. She has hit on a unique way to boost science in schools.

150 Year 9/10 students are presenting science shows to local primary students. And so far over 200 primary students have been excited dramatic demonstrations of plasma balls, hydrogen fuel, static electricity, flight and much more.

“The Energy Fair works at three levels,” says Dadson. “Firstly the fair empowers secondary students to talk about and demonstrate science – to rekindle and share their natural curiosity. Secondly, it gives primary students a great hands-on experience. And thirdly, when primary teachers see secondary students performing experiments, it shows them that science can be easier to demonstrate than they think.”

“We also show primary teachers how they can use the new Essential Learnings framework to teach students to inquire and question what they see around them. “

“And that’s what every young person is going to need to be an effective citizen in the 21st Century. Every day we face decisions about science – for pulp mills, to mobile phones, to cloning and gene technology. We need to give young people the knowledge and skills to rationally evaluate competing claims about science. This needs to start in primary school.”

Dadson hopes that every secondary school in Tasmania will pick up the concept.

“We’ve developed the Exeter Fair with the help of an Einstein Year grant from the Australian Institute of Physics, and a National Science Week grant (we did I put this in but don’t know if you did get Science Week money). We now have a manual that any school can use to run their own Energy Fair.

Students have been splitting water into hydrogen with a bang all last week. And this week there are two more sessions.

MEDIA ARE INVITED to come along and photograph students in action on Tuesday 30 August from 9.25am to 10.15am and on Wednesday 31 August from 10.40am to 11.30am